Saint Louis and its surrounding area are the home of several major universities, colleges, and higher education facilities:

• Saint Louis University, the oldest university west of the Mississippi River
• Parks College of Aviation and Aeronautical Sciences A division of SLU.
• Washington University in St. Louis
• Webster University
• University of Missouri - St. Louis
• Concordia Seminary of The Lutheran Church—Missouri Synod
• Fontbonne University
• Eden Seminary
• Southern Illinois University Edwardsville, one of the two Southern Illinois University system schools
• Lindenwood University
• Maryville University
• Harris-Stowe State College
• Hickey College
• Missouri Baptist University
• Ranken Technical College
• University of Phoenix - St. Louis Campus
• Saint Louis College of Pharmacy
• Missouri Tech University
• Kenrick Glennon Seminary
• National Academy of Beauty Arts
• Missouri College
• Deaconess College of Nursing
• Aquinas Institute of Theology
• Covenant Theological Seminary
• Allied Medical College
• Patricia Stevens College